Inside Precision Medicine Marketplace Translational Research UltiMapper® I/O Immuno8™

Ultivue
UltiMapper® I/O Immuno8™

Translational immuno-oncology research often requires the visualization of multiple cell phenotypes in FFPE tissue sections. Ultivue’s UltiMapper® I/O and U-VUE® kits allow for pre-optimized staining of up to 12 targets in a single tissue section using exchange technology with sequential imaging of targets across two or three imaging rounds. Final high-plex images require careful image alignment between scans to identify cell phenotypes in downstream analysis without artifacts from inappropriately overlapped cells, which can be achieved using Ultivue’s UltiStacker™ software.  

Utility of the Immuno8™ panel for whole-slide, single staining step multiplexing assay coupled to same slide H&E analysis provides exceptional data quality and throughput, with sample-to-analysis workflow achieved in a single workday executed manually or through automation using instrumentation and software solutions currently found in most immunohistochemistry laboratories. 




Ultivue

763D, Concord Ave
Cambridge, MA 02138
(617) 945-2662
https://www.ultivue.com





Features & Specs

  • Whole-slide imaging 
    • View the entire sample stained with 12 markers and nuclear counterstain removing bias of pre-defined ROIs 
  • Same-slide H&E 
    • Gather tissue multiplexing and tissue morphology data from the same sample 
  • Access to 256 distinct binary phenotypes 
  • Identify and characterize T-cell subsets, immunosuppressive cells, and interactions along the PD-1/PD-L1 checkpoint axis 
  • Panel consists of the following markers: CD3, CD4, CD8, CD68, FoxP3, PD-1, PD-L1, CK/SOX10 
  • Determine the presence of immunosuppressive macrophages 

Features & Specs

  • Whole-slide imaging 
    • View the entire sample stained with 12 markers and nuclear counterstain removing bias of pre-defined ROIs 
  • Same-slide H&E 
    • Gather tissue multiplexing and tissue morphology data from the same sample 
  • Access to 256 distinct binary phenotypes 
  • Identify and characterize T-cell subsets, immunosuppressive cells, and interactions along the PD-1/PD-L1 checkpoint axis 
  • Panel consists of the following markers: CD3, CD4, CD8, CD68, FoxP3, PD-1, PD-L1, CK/SOX10 
  • Determine the presence of immunosuppressive macrophages