Inside Precision Medicine Marketplace Oncology/Therapeutics High-quality Fc Receptors

ACROBiosystems
High-quality Fc Receptors

The efficacy of a therapeutic antibody not only depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors. The binding affinity of the Fc fragment towards FcRn (FCGRT&B2M) would predict the antibody’s half-life, while that between the Fc fragment and FcγRIIIa (CD16a) would influence the antibody’s ability to elicit ADCC (antibody dependent cell mediated cytotoxicity). Therefore, candidates must be tested against a panel of receptors during antibody engineering. ACROBiosystems offers a comprehensive collection of recombinant Fc receptor proteins, including their common variants, to expedite your antibody drug development.




ACROBiosystems

1 Innovation Way
Newark, DE 19711, USA
+1 800-810-0816
https://www.acrobiosystems.com/





Features & Specs

  • Expressed by HEK293 Cells: post-translational modification and proper protein folding
  • Multiple species: Human, Mouse, Cynomolgus/Rhesus macaque, Rat, Porcine, Rabbit, Feline, Bovine, can be fully applied to different cross species experiments
  • High purity: SDS-PAGE verification purity>95%, SEC-MALS verification purity>90%
  • Low endotoxin: low than 1.0 EU/µg
  • High stability: strict quality control to ensure high batch-to-batch consistency
  • Biotinylated Fc Receptor proteins labeled with AvitagTM offered.
  • Affinity verified by SPR and BLI, activity guaranteed. All protocols are available

Features & Specs

  • Expressed by HEK293 Cells: post-translational modification and proper protein folding
  • Multiple species: Human, Mouse, Cynomolgus/Rhesus macaque, Rat, Porcine, Rabbit, Feline, Bovine, can be fully applied to different cross species experiments
  • High purity: SDS-PAGE verification purity>95%, SEC-MALS verification purity>90%
  • Low endotoxin: low than 1.0 EU/µg
  • High stability: strict quality control to ensure high batch-to-batch consistency
  • Biotinylated Fc Receptor proteins labeled with AvitagTM offered.
  • Affinity verified by SPR and BLI, activity guaranteed. All protocols are available