Nearly 33 years ago, we started out on a voyage to solve a huge genomic puzzle, 13 years later we had the first three billion lettered draft of the human genome. This was a laudable feat, deserving of the recognition the scientific and political community bestowed upon those that contributed to its completion. The promises of how this would unlock a raft of incurable genetic diseases unfortunately didn’t materialize. Fast forward to this year, nearly two decades on, we have managed to fill in the gaps and create a complete genomic operating manual of human life. I hope this issue stimulates some thought around how far we’ve come and the ongoing path we need to follow. Educating as many as we can along the way will be one of our biggest challenges.